Program

 

Scientific Program

 

Thursday, March 17, 2016

08:00 – 08:45 Registration
08:45 – 09:00 Conference Opening
with Dr. Hendrik Lehnert (President, University of LŸübeck)
Session 1: Calicivirus Molecular Biology
Chair: Christiane Wobus (Ann Arbor, MI, USA)
09:00 – 09:45 Keynote I: Ian Goodfellow (Cambridge, United Kingdom)
Avoidance and control of the innateresponse during calicivirus infection
09:45 – 10:05 O1.1 – Steven Curry (London, United Kingdom),
New insights into the molecular mechanisms of the initiation of polyproteinsynthesis and processing in noroviruses
10:05 – 10:25 O1.2 – Myra Hosmillo (Cambridge, United Kingdom)
Characterisation of the mechanism of sapovirus translation initiation
10:25 – 10:45 O1.3 – Sreejesh Shanker (Houston, TX, USA)
Structure of a humannorovirus in complex with a neutralizing Ig A antibody reveals its mechanism of neutralization
10:45 – 11:15

Coffee Break

11:15 – 12:00 Keynote II: Robert Woods (Athens, GA, USA)
A role for underlying glycan structure in influenza binding: extending the species specificity paradigm
12:00 – 13:30

Lunch

Session 2: Virus Entry and Models of Infection
Chair: Ian Goodfellow (Cambridge, United Kingdom)
13:30 – 14:15 Keynote III: Stephanie Karst (Gainsville, FL, USA)
Commensal bacterial regulation of norovirus celltropism and immuneresponse
14:15 – 14:35 O2.1 – Gustav Rydell (Gothenburg, Sweden)
Norovirus glycosphingolipidinteractions
14:35 – 14:55 O2.2 – Mario Schelhaas (MŸünster, Germany)
Complexconformational changes in the capsid prime the papillomavirus capsid for receptor switching and entry
14:55 – 15:15 O2.3 – Samantha Wales (Laurel, MD, USA)
Using the human gut-on-a-chip system as a culture model for enteric virus infection
15:15 – 15:45

Coffee Break

15:45 – 16:30 Keynote IV: Christiane Wobus (Ann Arbor, MI, USA)
Norovirus entry into the Intestine
16:30 – 19:30

Get Together & Poster Session
with Beer & Pretzel

19:30 – 20:30

Guided Tour – Historic LŸübeck

Friday, March 18, 2016

Session 3: Antiviral Drug Design
Chair: Raoul de Groot (Uetrecht, Netherlands)
09:00 – 09:45 Keynote V: Mark von Itzstein (Brisbane, Australia)
From viral glycan receptors to drugs
09:45 – 10:05 O3.1 – Joana Rocha-Pereira (Leuven, Belgium),
The viral polymerase inhibitor 2Õ-C-methylcytidine sets the benchmark for the development of novel norovirus antivirals
10:05 – 10:25 O3.2 – Anna Koromyslova (Heidelberg, Germany)
Under attack: nanobodiestargeting humannorovirus capsid
10:25 – 10:45 O3.3 – Mila Leuthold (Heidelberg, Germany)
Analysis of fucosylated synthetic compounds binding to the norovirus capsid
10:45 – 11:15

Coffee Break

Session 4: Epidemiology, Evolution and Clinical Aspects I
Chair: Marion Koopmans (Rotterdam, Netherlands)
11:15 – 11:45 Keynote VI: Fred Zepp (Mainz, Germany)
Burden of community acquired norovirus gastroenteritis among hospitalized patients in Germany
11:45 – 12:00 O4.1 – Dieter Hoffmann (Munich, Germany)
Intra individual noroviral evolution analyzed by next generation sequencing
12:00 – 12:15 O4.2 – Soizick F. Le Guyader (Nantes, France)
Norovirus and oysters: impact of the species and of its genetic diversity
12:15 – 13:45

Lunch

Session 5: Epidemiology, Evolution and Clinical Aspects II
Chair: Jacques Le Pendu (Nantes, France)
13:45 – 14:00 O5.1 – Susana Guix (Barcelona, Spain)
Norovirus infections among symptomatic and asymptomatic food and healthcare workers in outbreak settings
14:00 – 14:15 O5.2 – Janet Mans (Pretoria, South Africa)
Norovirus epidemiology and diversity in South Africa (2009-2015): NoV GII.17 emerging
14:15 – 14:30 O5.3 – Louisa Ludwig (University of Lige, Belgium)
Regain of fitness through in vitro replication for a recombinant murine norovirus
14:30 – 14:45 O5.4 – Lydia Drumright (Cambridge, United Kingdom)
TaqMan Array Card assay is more sensitive than conventional RT-qPCR in detecting norovirus
14:45 – 15:30 Keynote VII: Marion Koopmans (Rotterdam, Netherlands)
Norovirus diversity and clinical impact, state of the art and knowledge gaps
15:30 – 16:00

Coffee Break

Session 6: Glycans as Drivers in Viral Infection I
Chair: Thilo Stehle (Tübingen, Germany)
16:00 – 16:45 Keynote VIII: Jacques Le Pendu (Nantes, France)
Glycans in enteric virus infection
16:45 – 17:05 O6.1 – Jesus Rodriguez-Diaz (Valencia, Spain)
Characterization of a novel conformational GII4 norovirus epitope: Implications in the immune escape and host receptor interactions
17:05 – 17:25 O6.2 – Zhen Li (London, United Kingdom)
Pinpointing epithelial glycanreceptors for rotaviruses by a novel ÔdesignerÕ microarray approach
17:25 – 17:45 O6.3 – Michael Buch (Tübingen, Germany)
Structural and functional analysis of murine polyomavirus capsid proteins establish the determinants of ligand recognition and pathogenicity
18:30 – 19:30

Reception by the Mayor of LŸübeck in the Historic Town Hall

20:00 –

Conference Dinner at the Media Docks

Saturday, March 19, 2016

Session 7: Vaccines R&D and Modeling
Chair: Stephanie Karst (Gainsville, FL, USA)
09:00 – 09:45 Keynote IX: Benjamin Lopman (Atlanta, GO, USA)
Modeling norovirus transmission and vaccination: implications of heterogeneity in innate human susceptibility
09:45 – 10:15

Coffee Break

Session 8: Glycans as Drivers in Viral Infection II
Chair: Mark von Itzstein (Brisbane, Australia)
10:15 – 11:00 Keynote X: Thilo Stehle (TüŸbingen, Germany)
Glycanbased viral receptors and their usefulness for antiviral therapy
11:00 – 11:15 O8.1 – Luisa Stršöh (TŸübingen, Germany)
Structuralanalysis and evolution of glycanreceptor specificities of newly discovered humanpolyomaviruses
11:15 – 11:30 O8.2 – Julia LockhauserbŠäumer (Hamburg, Germany)
Specific glycansincrease the success of viral infections: native MS revealglycanmediated structuralchanges during cellattachment
11:30 – 12:30

Lunch / Boxed Lunch

12:30 – 12:45 O8.3 – Henrik Wegener (LŸübeck, Germany)
Recombinant norovirus GII.4 P dimercontainssialic acid and histo-blood group antigen binding sites
12:45 – 13:00 O8.4 – Alvaro Mallagaray (LŸübeck, Germany)
Attachment of norovirus to histo-blood group antigens and gangliosides: a cooperative multistep process
13:00 – 13:45 Keynote XI: Raoul de Groot (Utrecht, Netherlands)
Virus-sialic acid interactions: sweet but not that sweet
13:45 – 14:00

Closing Remarks and Poster Prize


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